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KMID : 0378019860290040051
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New Medical Journal
1986 Volume.29 No. 4 p.51 ~ p.64
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Nutritional Modification on Pathogenesis of Liver Carcinogenesis
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Abstract
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Multistage process of hepatocellularcarcinogensis can be thought under the gen-ral sequence cf initiati0. , promotion, and progression. Putative precursors of hepatocellular carcinoma have been referred to as enzyme-altered foci and hyperplastic nodules in w ich. gamma-glutamyl Iran spetidase is generally increased and glucose-6-phosphatase and adenosine triphophatase are decreased. Autoradiographic labeling indeces of triti : ted thymidine afe usually higher in these lesions than in surrounding hepatocytes. In o her words, the later is the process of tumorogenesis, the higher in labeling indices. Through the extensive review of many experimental models, we can understand that the replication of hepatocytes induced, by partial hepatectomy resulted from chemical, dietary and or viral partial hepatectomy is a common important factor in pathogenesis of 1 ver cancer. Moreover, it is suggested that activation and amplification of proto-oncogenes are closely related with regeneration of hepatocytes. Possible roles of nutritional modificat ons on the development of hepatocellular cancer are considered.
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KEYWORD
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